Sjsz PVC Twin Screw Pipe Making Extruder Production Line

Product Description

mall PVC wire pipe machine Production Line details:
 
1.AC motor,ABB frequency speed governor, Japanese RKC temperature controller, Schneider contactor.
 
2.Screw Nitriding treatment,hardness HV740-940,surface roughness Ra≤ 0.8um.
 
3.Barrel air-cooled cooling method, nitriding depth of 0.5- 0.7mm, hardness of HV860 or more, the surface roughness Ra ≤ 1.6um.
 
4.Die head material,High quality steel by quenching and tempering.Structure,Where contact with the materials hard chrome plating.Bolts level,12.9 high strength bolts.
 
5.Two Vacuum calibration tank material:Stainless steel.
 
6.Double Caterpillar adjusting method: pneumatic compress device.
 
7.Double cutter: Most cutting times,20 times/min;With strong waste clean device. Equipped with a meter installation, meter size is accurate.    
 
8.Double stacker: Pneumatic flip, soft rubber, to prevent pipe surface scratch.
 
9.All electrical parts adopt world famous brand product.
 
Extruder For PVC small diameter conduit Pipe machine :
  Conical Twin Screw Extruder

A: Counter Rotating Conical twin screw machined on CNC make thread milling machines by simulation software for better performance.

B: Conical twin screw extruder is specially designed for high calcium loading.

C: Compact & reliable gear box

D: Synchronized drives of the extruder, feeder, and haul-off enable the ease of operation. It is designed for high output at low screw speed and less power consumption.

E: Bi-metallic screw & barrel can be provided for two -three times more lifespan than nitrided screw and barrel.

Die Head

A: Die head is made of high carbon content forgedalloy steel for better life and performance.
B: It has resonable flow channel design and special treatment on the surface;
C: Special flow channel design ensures the equal distribution of PVC in the mould;
D: Melt temperature and pressure remain even.

Spraying Bath

A: Intensive cooling of the pipe with the help of number of spraying nozzles;

B: Axial adjustment of thank on slide rails with locking arrangement;

C: Self cleaning type spray nozzle with wide opening for intensive cooling of the pipe;

D: Acrylic transparent cover for easy inspection.

Pneumatic Haul Off

A; Twin and multi-track system;

B: Track can be adjusted for different sizes of pipe ranging between 20mm and 800mm;

C: Hall-off is synchronized with extruder with the help of AC frequency variable drive;

D: Gap between two tracks and pressure is adjusted pneumatically;

E: V-Groove rubber pads mounted on chain with proper tensioning to prevent ovality for large even for large diameter and think wall pipes.

Planetary Cutting saw

A: Planetary saw blades cutting for pipe diameter up to 800mm;

B: Rotary cutting make sure smooth and clean;

C: Cutting is PLC controlled;

D: Saw dust powerful sucking device

E: Special hard alloy saw blade is employed to cut heavy caliber thick wall pipes.

Factory


Details


Our Service
1. One year guarantee for whole machine
2. 24 hours technical support 
3. Our engineers can provide service overseas. The service is free, but the charge of round air-tickets, food and hotel is to the customer's account.
4. After a year, we can instruct you how to maintain the machine, and spare parts are provided with the best price.
5. We also can provide training service which help operators handle the machine well.

 
We are the manufacturer specialized in plastic machine manufacture for many years,our products are exported to many countries.If you are interested in our products,please contact us at any time.

Tofacitinib Intermediates

Tofacitinib is an orally available inhibitor of Janus kinases (JAK), with immunomodulatory and anti-inflammatory activities. Upon administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription (STAT) signaling pathway. This may decrease the production of pro-inflammatory cytokines, such as interleukin (IL)-6, -7, -15, -21, interferon-alpha and -beta, and may prevent both an inflammatory response and the inflammation-induced damage caused by certain immunological diseases. JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis, immunity and inflammation.

Tofacitinib is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis, psoriatic arthritis and inflammatory bowel disease. Tofacitinib is associated with transient and usually mild elevations in serum aminotransferase levels during therapy, but has yet to be linked to cases of clinically apparent acute liver injury.

Tofacitinib is a pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor and an antirheumatic drug. It is a pyrrolopyrimidine, a N-acylpiperidine, a nitrile and a tertiary amino compound.

The chemical system of tofacitinib citrate is 3 - {(3R, 4R) - 4-methyl-3 - [methyl - (7H-pyrrolo [2,3-d] pyrimidin-4-yl) - piperidin-1-yl] - 3-oxo-propionitrile citrate. Chemical book is a Janus kinase inhibitor developed by Pfizer. On November 6, 2012, the US Food and Drug Administration (FDA) approved the substance as a drug on the market for the treatment of adult patients with moderate to severe active rheumatoid arthritis (RA) who do not respond or tolerate methotrexate.

Tofatib is suitable for adult patients with moderate to severe active rheumatoid arthritis (RA) who have insufficient or intolerable efficacy of methotrexate. It can be used in combination with methotrexate or other non biological anti rheumatic drugs (DMARD).

Tofatinib citrate is a drug for rheumatoid arthritis developed by Pfizer pharmaceutical company of the United States. It is used in adults with moderate to severe active rheumatoid arthritis (RA) who have insufficient or intolerable response to methotrexate. This product is a Janus kinase inhibitor, which is taken twice a day. On November 6, 2012, the food and Drug Administration (FDA) and Pfizer jointly announced that tofatinib citrate was approved for adult patients with moderate to severe active rheumatoid arthritis (RA) who had insufficient or intolerable response to methotrexate treatment. Xeljanz can be used as a single treatment or in combination with methotrexate or other nonbiological disease relief anti rheumatism drugs (DMARD). The drug should not be used in combination with biological DMARD or strong immunosuppressants such as azathioprine and cyclosporin. The approved dose of xeljanz was twice a day, 5mg per time. Seven clinical trials evaluated the safety and effectiveness of tofatinib citrate in adults with moderate to severe active rachemicalbook. In all trials, patients treated with xeljanz had significant improvement in clinical response and physical function compared to those who received placebo. In clinical trials, the most common adverse reactions were upper respiratory tract infection, headache, diarrhea, nasal congestion, throat pain and nasopharyngitis. The use of xeljanz is associated with increased risk of serious infection, including opportunistic infections, tuberculosis, cancer and lymphoma. The xeljanz product label contains framed warnings about these security risks. The treatment of xeljanz was also related to the increase of cholesterol and liver enzyme values and the decrease of blood cell count. To study the long-term effects of xeljanz on heart disease, cancer and severe infections, FDA requires a post market study that will assess two doses of xeljanz (tofatinib citrate) treatment and include it in a control group that received another approved treatment.

Our Tofacitinib API And Intermediates is as following,we have all the below API and intermedites offering all year.
Tofacitinib Intermediate Cas 3680-69-1,Tofacitinib Cas 3680-69-1

Tofacitinib Intermediate Cas 3680-69-1,Tofacitinib Cas 3680-69-1,Tofacitinib Intermediate Preparation,Intermediates Of Tofacitinib;rheumatoid arthritis (RA)

 Shandong Haohong Biotechnology Co., Ltd. , https://www.haohongpharma.com